With the given diversity and abundance of several targets of miRNAs, they functionally appear to interact with diverse elements of the multiple cellular networks such as cell growth and development, differentiation, proliferation, and apoptosis. They thereby function either as tumor suppressors or oncogenes, whose under or overexpression plays a significant role in the development and progression of several cancers such as leukemia, liver, lung, pancreatic, colorectal and ovarian cancer which have also been established to be Age Related Disorders (ARD). Since miRNAs have been implicated as prospective regulators of age-related diseases or disorders, the interlinking of miRNAs and longevity can demonstrate the role of miRNAs in the regulation of the aging process and its related disorders.
We have, thus, comprehensively curated all miRNAs reported to be associated with both ARD (Age Related Disorders) and cancers in the human genome and established a database that stores all miRNAs related to both the diseases along with its target genes. The database currently houses 1648 miRNAs associated with both cancers and ARD comprising of 38 variants supported with pertinent data. Also, the database includes the corresponding miRNA sequences, its chromosome number, and location.
Venn Diagram for common MiRNAs between ARDs and Cancer
MiRNA target genes pathway analysis